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The Effect of Dexmedetomidine on Agitation During Weaning From Mechanical Ventilation

The Effect of Dexmedetomidine on Agitation During Weaning From Mechanical Ventilation

Recruiting
19 years and older
All
Phase N/A
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Overview

This study aims to evaluate the effect of dexmedetomidine on the level of agitation during the weaning process from mechanical ventilation in critically ill patients.

Eligibility

Inclusion Criteria:

  • Adult ICU patients (≥18 years).
  • On mechanical ventilation ≥24 hours.
  • Clinically ready for weaning.
  • Agitation score RASS ≥ +1 during spontaneous breathing trial.
  • Intubation for at least 4 days: 2 weeks.

Exclusion Criteria:

  • Known hypersensitivity to dexmedetomidine.
  • Hemodynamic instability (HR < 50 bpm or MAP < 60 mmHg).
  • Neurological impairment affecting level of consciousness.
  • Pregnancy or lactation.

Study details
    Dexmedetomidine

NCT07066605

Sohag University

16 October 2025

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