Overview

To evaluate the safety and tolerability of a single subcutaneous injection of HRS-9563 in hypertensive subjects

Eligibility

Inclusion Criteria:

1. Males or infertile women aged 18-65 years (inclusive);
2. Body mass index in the range of 19-28 kg/m2 (inclusive);
3. Mild primary hypertension, without antihypertensive treatment, with a mean sitting systolic blood pressure ≥ 130 mmHg and ≤ 159 mmHg during screening and baseline, and a mean 24-hour ambulatory systolic blood pressure ≥ 130 mmHg during screening.

Exclusion Criteria:

1. Abnormal daily life rhythm;
2. Any blood biochemical indicator during screening or baseline did not meet the standards in the exclusion criteria;
3. Secondary hypertension;
4. Mean sitting diastolic blood pressure ≥ 100 mmHg;
5. Orthostatic hypotension;
6. History of type 2 diabetes mellitus or poorly controlled blood glucose;
7. Recently received any antihypertensive medications or medications that affect blood pressure.