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Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study

Characteristics of Hypophosphatasia in Adult Patients in Rheumatology and Their Value in Developing an Algorithm to HPP-diagnosis - the COHIR Multi-center Study

Recruiting
18 years and older
All
Phase N/A
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Overview

Non-interventional, prospective, multi-center investigation with exploratory data analysis to assess the proportion of patients with hypophosphatasia presenting at departments of rheumatology and to establish an algorithm to HPP diagnosis

Description

Acronym: Expansion:

HPP =Hypophosphatasia COHIR ="Characteristics of Hypophosphatasia in Adult Patients in Rheumatology" ALPL =Alkaline Phosphatase

Eligibility

Inclusion Criteria:

  • Written informed consent
  • Age > 18 years
  • Clinical suspicion of hypophosphatasia
  • Evidence of an abnormal ALP (ALP below LLN) within the clinical routine screening

Exclusion Criteria:

  • Failure to meet the inclusion criteria listed above

Study details
    Hypophosphatasia

NCT06574282

University of Bonn

16 October 2025

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