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HighCycle Study: Effect of High Altitude on Sleep Disordered Breathing in Women Related to Their Menstrual Cycle Phase

HighCycle Study: Effect of High Altitude on Sleep Disordered Breathing in Women Related to Their Menstrual Cycle Phase

Recruiting
18-44 years
Female
Phase N/A
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Overview

Prospective cohort study investigating the menstrual cycle phase (MCP) dependent sleep disordered breathing (SDB) in women travelling to 3600 m.

Eligibility

Criteria: Inclusion Criteria:

  • Healthy, non-smoking women, age 18-44 years, without any diseases and need of regular medication (including oral contraceptives).
  • BMI >18 kg/m2 and <30 kg/m2
  • Born, raised and currently living at altitudes <1000 m
  • Written informed consent
  • Premenopausal, eumenorrheic cycle

Exclusion Criteria:

  • Other types of contraceptives (hormonal intrauterine device, vaginal ring, subcutaneous injections or implants, among others)
  • Pregnancy or nursing
  • Anaemic (haemoglobin concentration <10g/dl)
  • Any altitude trip <4 weks before the study
  • Allergy to acetazolamide and other sulfonamides

Study details
    Sleep-Disordered Breathing

NCT06498544

University of Zurich

16 October 2025

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