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The Efficacy of Fluticasone Furoate/Vilanterol/Umeclidinium Compared With Vilanterol/Umeclidinium in Reducing Air Trapping and Airway and Blood Cytokine Levels in COPD

The Efficacy of Fluticasone Furoate/Vilanterol/Umeclidinium Compared With Vilanterol/Umeclidinium in Reducing Air Trapping and Airway and Blood Cytokine Levels in COPD

Recruiting
40-80 years
All
Phase 3
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

This study aims to demonstrate the effects of triple therapy (ICS/LABA/LAMA) and dual bronchodilators (LAMA/LABA) on air trapping in the lungs' COPD patients and inflammatory mediators

Eligibility

Inclusion Criteria:

  • Patients who have met the criteria for COPD GOLD B defined by an exacerbation not more than 1 time in the last year prior to the study enrollment. These patients will be recruited in sequential sequence.
  • Patients with COPD GOLD B are previously treated with either LAMA or LAMA/LABA or short-acting bronchodilators
  • Patients who are able to provide informed consent.

Exclusion Criteria:

  • - Concomitant with active and old pulmonary TB, lung cancer, bronchiectasis, lung fibrosis, destroyed lung, other malignancy, active heart diseases.
  • Receiving long-term treatment with immunosuppressive drugs and systemic corticosteroids
  • Being treated with triple therapy (ICS/LABA/LAMA)
  • Being in terminally ill conditions

Study details
    COPD

NCT06474039

Mahidol University

16 October 2025

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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