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Randomized Control Trial of Sleeve Gastrectomy with Tirzepatide in Maximizing Weight Loss

Randomized Control Trial of Sleeve Gastrectomy with Tirzepatide in Maximizing Weight Loss

Recruiting
18-65 years
All
Phase N/A
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Overview

This study examines whether adding tirzepatide-a medication that helps with weight loss-after sleeve gastrectomy surgery can help people lose more weight after the surgery; better improve conditions like Type 2 diabetes, high blood pressure, high cholesterol, and sleep apnea after surgery and; whether this causes more complications or side effects compared to surgery alone.

Eligibility

Inclusion Criteria:

  • Adult 18 to 65 years of age
  • Body Mass Index >35 with comorbidity of Type 2 Diabetes and/or Hypertension and/or Hyperlipidemia and/or Obstructive Sleep Apnea OR Body Mass Index >40 with or without comorbidity
  • Undergoing primary sleeve gastrectomy

Exclusion Criteria:

  • Prior metabolic and bariatric surgery
  • Prior use of GLP-1 agonist
  • Prior history of pancreatitis
  • Personal/family history of medullary thyroid cancer or MEN type 2
  • Secondary cause of obesity
  • Any eating disorder
  • Pregnancy/lactation
  • History of acute coronary syndrome or myocardial infarction
  • History of stroke
  • Hepatic dysfunction: AST/ALT >3 ULN
  • Renal dysfunction eGFR<45ml/min/1.73m2
  • Active malignancy
  • History of diabetic retinopathy
  • History of gastroparesis

Study details
    Obesity and Obesity-related Medical Conditions

NCT06734273

Nicholas Skertich

16 October 2025

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