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Efficacy of MitraCLip Vs. PASCAL for the TrEAtment of MitraL REgurgiTation in an All-comer Population

Efficacy of MitraCLip Vs. PASCAL for the TrEAtment of MitraL REgurgiTation in an All-comer Population

Recruiting
18 years and older
All
Phase N/A

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Overview

To investigate potential differences in procedural outcomes of both commercially available transcatheter edge-to-edge mitral valve repair devices in a non-selected clinical setting.

Description

In the context of M-TEER, two different systems (MitraClip vs. PASCAL) are CE certified and clinically available. In the case of non-complex anatomy, both systems are comparable in terms of effectiveness. Whether this holds true in cases of complex or highly complex anatomy in an "Allcomer patient population" is currently unclear.

Eligibility

Inclusion Criteria:

  • Age equal or above 18 years
  • Written consent
  • Heart Team recommends M-TEER

Exclusion Criteria:

  • Mitral Stenosis (MV mean PG > 5 mmHg)
  • Cardiogenic shock or hemodynamic instability at the time of intervention
  • Active endocarditis
  • Participant in another interventional cardiology study

Study details
    Mitral Regurgitation
    Valvular Heart Disease
    Heart Failure

NCT06634121

LMU Klinikum

16 October 2025

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