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A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)

A Natural History Study of Corneal Abrasions in Patients With Dystrophic Epidermolysis Bullosa (DEB)

Recruiting
6 years and older
All
Phase N/A
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Overview

This study is a non-interventional, observational study that will evaluate the natural history of corneal abrasions in patients with Dystrophic Epidermolysis Bullosa (DEB).

Description

The objective of this study is to characterize the natural history of corneal abrasions in patients with Dystrophic Epidermolysis Bullosa (DEB). Patients will be followed via remote weekly symptom diaries and monthly questionnaires to assess corneal abrasion symptoms, frequency, and duration.

Eligibility

Inclusion Criteria:

  1. The subject or their respective legal guardian must have read, understood, and signed an Institutional Review Board (IRB) approved Informed Consent/Assent Form and must be able to and willing to follow study procedures and instructions.
  2. Age 6 months or older at time of Informed Consent/Assent.
  3. Prior genetic diagnosis of DEB due to mutation(s) in the collagen type VII alpha 1 chain (COL7A1) gene.

Study details
    Epidermolysis Bullosa Dystrophica
    Epidermolysis Bullosa Dystrophica
    Recessive
    Epidermolysis Bullosa Dystrophica Dominans

NCT06563414

Krystal Biotech, Inc.

16 October 2025

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