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Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures

Effects of Relighting on Smoke Toxicant Deliveries and Subjective Smoking Measures

Recruiting
21 years and older
All
Phase N/A

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Overview

Characterize effects of relighting on smoke toxicant deliveries and subjective smoking measures. This will be a within-subject comparison in a single experimental group of 30 smokers who report engaging in relighting behaviors. We will assess smoking intensity for relit and non-relit (i.e., smoked continuously without relighting) cigarettes in the natural environment and will conduct in-clinic measurements of smoking topography and subjective responses for relit and non-relit cigarettes. Information on relighting patterns and smoking topography collected from each participant will be used to compare machine-measured smoke yields of key harmful constituents when their usual cigarettes are smoked with and without relighting. Hypothesis: Relit cigarettes will produce higher levels of toxicants than non-relit cigarettes.

Eligibility

Inclusion Criteria:

  • Smoking at least 10 cigarettes/day for at least 1 year (confirmed by CO > 8 ppm or NicAlert test of 6)
  • Engaging in relighting for at least half of their CPD
  • No smoking quit attempts in the past month nor intentions to quit in the next month
  • Stable medical or psychiatric conditions with systolic blood pressure < 160, diastolic blood pressure < 100 and heart rate < 105 bpm

Exclusion Criteria:

  • Participant with current or recent alcohol or drug abuse problems, use of substances of abuse (other than marijuana due to high prevalence of co-use) within the past month
  • Currently trying or planning to quit smoking in the next month
  • Planning to become pregnant, pregnant or breastfeeding. Pregnancy exclusion will be confirmed through a urine test.

Study details
    Tobacco Use
    Cigarette Smoking
    Nicotine Dependence

NCT06295757

Masonic Cancer Center, University of Minnesota

16 October 2025

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