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Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease (ANOCA-CMD)

Coronary Microvascular Dysfunction in Angina Patients With Non-obstructive Coronary Artery Disease (ANOCA-CMD)

Recruiting
18 years and older
All
Phase N/A
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Overview

The goal of this observational study is to explore the incidence and effect on prognosis of coronary microvascular dysfunction in patients present of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (FFR) >0.80.

Eligibility

Inclusion Criteria:

  • presence of stable anginal symptoms, a clinical indication for invasive coronary angiography, and no hemodynamically significant epicardial coronary artery disease, defined as fractional flow reserve (FFR) >0.80

Exclusion Criteria:

  1. acute myocardial infarction
  2. significant valvular heart disease
  3. advanced chronic kidney disease
  4. patients with significant epicardial coronary artery stenosis (>70% in major vessels by diagnostic coronary angiography) needing percutaneous coronary intervention
  5. patients unable to provide written informed consent

Study details
    Angina Patients With Non-obstructive Coronary Artery Disease
    Coronary Microvascular Dysfunction
    Index of Microvascular Resistance

NCT06503640

China-Japan Friendship Hospital

16 October 2025

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