Overview
The goal of this observational study is to understand the clinical variability in a population of ALS patients using multidimensional biomarkers. The main questions it aims to answer are:
- Which set of biomarkers explain genotypic-phenotypic correlations in ALS?
- Which set of biomarkers can be used to subdivide the ALS population in homogeneous subgroups?
Participants will undergo:
- neurological evaluation
- neurophysiological evaluation
- neuropsychological evaluation
- whole exome sequencing
- biomarker measurement in CSF and plasma
Eligibility
Inclusion Criteria:
- diagnosis of ALS or other motor neuron disease
- residence near the study centers
Exclusion Criteria:
- refusal to participate to the study
- unable/unwilling to perform follow-up visits