Overview
This study was conducted to investigate effects of postbiotics on mood disorders in korean adults
Description
This study is an 8-week, randomized, double-blind, placebo-controlled, parallel-group clinical trial. 52 participants were randomly assigned to either the postbiotics intervention group or a placebo group. The study aimed to evaluate the effects of postbiotics on mood disorders in Korean adults, comparing pre- and post-intervention mood profiles.
Eligibility
Inclusion Criteria:
- Adults aged between 19 and 39 years at the time of screening.
- BMI between 18.5 and 30 at the time of screening.
- CES-D (Center for Epidemiologic Studies Depression Scale) score of 16 or higher.
- Ability to access and respond to the survey via an online link.
Exclusion Criteria:
- Participation in any human clinical trial within the past 3 months before screening.
- History of antipsychotic medication treatment within the past 3 months before screening.
- Presence of chronic diseases, including cardiovascular, endocrine, immune, respiratory, hepatobiliary, renal and urological, neurological, musculoskeletal, inflammatory, hematological, oncological, or gastrointestinal disorders.
- Use of medications or health supplements related to gut health and mood disorders (e.g., antibiotics, laxatives, antidiarrheals, prebiotics, probiotics, postbiotics, anxiolytics, antidepressants, etc.) within 1 month prior to participation in the study.
- History of significant hypersensitivity to postbiotics or starch.
- Alcohol addiction, drug abuse, or suspicion of substance misuse.
- Pregnant or breastfeeding women.
- Any other reasons that the study investigator deems the participant unsuitable for participation.