Overview
To evaluate the objective response rate, disease control rate, progression-free survival, overall survival, surgical conversion rate and safety of irinotecan liposome combined with 5-FU/LV+ bevacizumab regimen in first-line treatment of advanced metastatic colorectal cancer patients.
Description
This is a Phase II clinical study to evaluate the efficacy and safety of the combination regimen of irinotecan liposome injection in the first-line treatment of metastatic colorectal cancer. Patients will receive liposomal injections of irinotecan 70mg/m^2 d1, bevacizumab 5mg/kg d1, LV 400mg/m^2 d1, 5-FU 400mg/m^2, then 2400mg/m^2, continuous intravenous infusion for 46-48h, d1-2. 86 eligible patients will be enrolled.
Eligibility
Inclusion Criteria:
- 18~85 years old.
- Histopathologically confirmed patient with an inoperable metastatic colorectal adenocarcinoma.
- RAS/BRAF v600e mutant or right half colon cancer is known.
- pMMR/MSS is known.
- The unresectable stage of metastatic disease has not received any systemic antitumor therapy.
- For subjects previously receiving neoadjuvant or adjuvant therapy, the date of first discovery of disease progression must be at least 6 months removed from the date of last administration of neoadjuvant or adjuvant therapy.
- ECOG 0~1, patients ≥75 years old need an ECOG score of 0
- The presence of at least 1 measurable lesion that can be evaluated according to the RECIST v1.1 criteria.
- Normal bone marrow and organ function: ① Neutrophils (ANC) ≥1.5×10^9/L, platelets (PLT) ≥100×10^9/L, hemoglobin (Hb) ≥80g/L, albumin (ALB) ≥30 g/L, white blood cells (WBC) ≥3.0×10^9/L, and no bleeding tendency; ② AST, ALT and alkaline phosphatase (ALP) were all ≤2.5× upper limit of normal range (ULN), and ≤5×ULN when liver metastases occurred; The total bilirubin level doesn't exceed the upper limit of the agency's normal range; Serum creatinine (Cr) ≤1.5×ULN or creatinine clearance ≥40 ml/min (calculated according to Cockroft-Gault)
- Understand the situation of this study, patients and/or legal representatives voluntarily agree to participate in this study and sign informed consent form.
Exclusion Criteria:
- Known or suspected central nervous system metastasis.
- Received irinotecan/irinotecan liposomes/bevacizumab before enrollment.
- Had undergone surgery and other oncologic treatments within the first 4 weeks of enrollment.
- Previous treatment-related toxicity didn't return to NCI-CTCAE v5.0 I or below(except hair loss and peripheral neuropathy).
- The use of CYP3A, CYP2C8, and UGT1A1 inhibitors or inducers couldn't be discontinued or were not discontinued within 2 weeks prior to enrollment.
- Severe gastrointestinal dysfunction, gastrointestinal perforation, intraperitoneal abscess, and fistula.
- Intestinal obstruction, signs and symptoms of intestinal obstruction, or the stent has been previously implanted and the stent has not been removed before the screening period.
- Interstitial lung disease.
- Tendency of arterial embolism and massive bleeding within 6 months before enrollment (except surgical bleeding).
- Patients with fluid accumulation that couldn't reach a stable state but small amount of ascites on imaging without clinical symptoms could be enrolled.
- Any serious or uncontrolled systemic disease, including uncontrolled high blood pressure, heart disease, active bleeding, active viral infection, etc.
- Have had other malignancies within the past 5 years or currently, except cured cervical carcinoma in situ, uterine carcinoma in situ, and non-melanoma skin cancer.
- Patients of childbearing age who refuse to take contraceptives, women who are pregnant or breastfeeding.
- The researchers didn't consider it appropriate to participate in this study.