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Observational Study for the Evaluation of Immune-mediated Endocrinological Adverse Events in Patients With Hematological Malignancies and Subjected to Treatment With Immune-checkpoint Inhibitors

Observational Study for the Evaluation of Immune-mediated Endocrinological Adverse Events in Patients With Hematological Malignancies and Subjected to Treatment With Immune-checkpoint Inhibitors

Recruiting
18 years and older
All
Phase N/A
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Overview

Retrospective / prospective observational study of endocrinological adverse events in hematologic patients treated with immunological checkpoint inhibitors

Eligibility

Inclusion Criteria:

Retrospective cohort

  • patients aged> 18 years
  • cyto-histological diagnosis of mature lymphoproliferative syndrome of B or T lymphocyte origin
  • advanced stage of illness (relapsed or refractory)
  • patients undergoing treatment with immune anticheckpoint antibodies.
  • written informed consent

Prospective cohort

  • patients aged> 18 years
  • cyto-histological diagnosis of mature lymphoproliferative syndrome of B or T lymphocyte origin
  • advanced stage of illness (relapsed or refractory)
  • patients who are candidates for therapy with anticheckpoint immune antibodies (it is specified that this therapy is completely independent of the subject's participation in the study).
  • written informed consent

Exclusion Criteria:

  • Severe, acute and chronic medical or psychiatric disorders that may affect the interpretation of the study results or interfere with it.

Study details
    Hematological Malignancies

NCT06851702

IRCCS Azienda Ospedaliero-Universitaria di Bologna

16 October 2025

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