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Team Science (The Liver Health Study)

Team Science (The Liver Health Study)

Recruiting
21 years and older
All
Phase N/A

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Overview

Liver damage from alcohol intake and weight-related behaviors is preventable and treatable only through lifestyle changes. This mixed-methods randomized controlled trial compares standard and enhanced approaches to screening, brief intervention, and referral to treatment/prevention (SBIRT/P) to identify and intervene for metabolism- and alcohol-associated liver disease (MetALD). Our multidisciplinary team aims to show that integrating results of noninvasive liver screening with Fibroscan®, a painless ultrasound that measures stiffness and fat in the liver, can optimize our brief intervention. The study population is adults age 21+ who speak Spanish or English from underresourced communities with alcohol- and weight-related risks for MetALD.

Eligibility

Inclusion Criteria:

  • Be at least 21 years of age.
  • Exceed alcohol intake screening guidelines for MetALD.
  • Have a Body Mass Index (BMI) >=25 kg/m2.
  • Be able to speak and read English or Spanish to provide written informed consent and understand written and oral instructions in English or Spanish.

Exclusion Criteria:

  • Pre-existing liver disease or hepatocellular carcinoma or prior liver transplant.
  • Pre-existing medical conditions that, in the opinion of the investigative team, would interfere with research participation (e.g., loss of kidney function, uncontrolled infections, multiorgan failure, uncontrolled upper gastrointestinal bleeding, other active malignancies except skin cancer).
  • Pre-existing mental health conditions that, in the opinion of the investigative team, would interfere with the ability to provide informed consent and understand written and oral instructions (e.g., hepatic encephalopathy, psychotic disorder diagnosis or symptoms).
  • Current pregnancy.
  • Be anyone who, based on self-reported withdrawal symptoms and the opinion of the investigative team, could not currently safely be withdrawn from alcohol without medical detoxification.
  • Currently receiving formalized psychosocial treatment for an alcohol use or drug problem and/or newly taking medications for an alcohol use or drug problem.
  • Currently receiving formalized behavioral weight management treatment and/or newly taking weight loss medications.

Study details
    Steatotic Liver Disease of Mixed Origin (MetALD)

NCT06924281

Brown University

21 October 2025

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