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Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis

Interrogating the Pathophysiological Mechanisms of Constipation in Patients With Systemic Sclerosis

Recruiting
18 years and older
All
Phase N/A
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Overview

The purpose of this study is to determine whether transcutaneous electrical acustimulation (TEA) alters systemic sclerosis (SSc)-related colonic and anorectal physiology by enhancing autonomic nervous system (ANS) function. The study will examine the effects of TEA on slow colonic transit (SCT) and rectal hyposensitivity (RH), to examine whether TEA improves autonomic dysfunction and modulates inflammatory pathways.

Eligibility

Inclusion Criteria

  • Patients with SSc-constipation from Aim 1 of the study
  • Patients with SCT (>20% radiopaque marks left in the colon 5 days (120 hours) after swallowing the Sitzmark capsule or patients with RH (defined in Aim 1)
  • Patients not yet on therapy for constipation or patients who continue to experience constipation while on stable therapy for one month prior to TEA.

Exclusion Criteria

-Patients with symptoms of both diarrhea and constipation but not predominantly symptoms of constipation.

Study details
    Systemic Sclerosis
    Constipation
    Gastrointestinal Motility Disorder
    Autonomic Dysfunction

NCT05989763

The University of Texas Health Science Center, Houston

16 October 2025

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