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The "New" Place of LEVETIRACETAM in the Management of Status Epilepticus in Children

The "New" Place of LEVETIRACETAM in the Management of Status Epilepticus in Children

Recruiting
3-17 years
All
Phase N/A

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Overview

Status epilepticus is the leading neurological emergency in children, with mortality 2-7% and significant morbidity (10-20%). It is defined as the occurrence of a crisis lasting more than 5 minutes and requiring the implementation of treatment to stop it and thus limit the immediate and long-term consequences.

The research hypothesis is that LEVETIRACETAM is non-inferior to PHENYTOIN in terms of cessation and absence of recurrence of status epilepticus, with better clinical tolerance in children from 3 months to 17 years old, with or without epileptic disease, with or without a history of status epilepticus

Eligibility

Inclusion Criteria:

  • Minor patient aged 3 months to 17 years
  • 2nd line treatment with LEVETIRACETAM or PHENYTOIN after failure of benzodiazepines
  • Supported in one of the participating centers during the period from November 1, 2019 to May 31, 2023
  • Subject or parents who have not expressed, after information, their opposition to the reuse of their data for the purposes of this research.

Exclusion Criteria:

  • Patient or parents having expressed their opposition to participating in the study.

Study details
    Epilepsy in Children

NCT06498362

University Hospital, Strasbourg, France

21 October 2025

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