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Clinical Investigation of a Novel Spectacle Lens on Slowing Down Juvenile Myopia Progression

Clinical Investigation of a Novel Spectacle Lens on Slowing Down Juvenile Myopia Progression

Recruiting
6-11 years
All
Phase N/A

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Overview

The goal of this exploratory clinical trial is to evaluate the efficacy and safety of a test spectacle lens (standard single vision lens (SVL) during first year, and standard myopia control lens (MCL) in second year), designed with passive red-light emission, for the control of myopia progression in myopic children age 6 to 11 years old, both male and female, with no systemic or ocular anomalies. The main question it aims to answer is:

Does the test spectacle lens designed with passive red-light emission provide significant myopia control effect to children?

Researchers will compare the standard SVL designed with passive red-light emission to SVL (first year) and MCL designed with passive red-light emission to MCL (second year) to see if the test spectacle lens work to slow down myopia progression.

Participants will:

  • Wear the study spectacles
  • Visit Essilor R&D Centre for follow-up sessions

Eligibility

Inclusion Criteria:

  • Children equal to or greater than 6 years old and less than 11 years at the time of signing informed consent.
  • Corrected spherical equivalent refraction (SER) between -0.75 D and -5.00 D with astigmatism not more than 2.50 D.
  • Difference in SER (Anisometropia) between two eyes should not exceed 1.00 D.
  • Best corrected visual acuity better than or equal to +0.10 log MAR (20/25 or better with Snellen).
  • Be in good general health, based on his/her and parent's/guardian's knowledge.
  • Agree to wear spectacles for >12 hours/day and at least 6 days/week.
  • Willingness and ability to participate in investigation for 2 years and attend scheduled visits.

Exclusion Criteria:

  • Any ocular or systemic pathologies known to affect refractive status (e.g. keratoconus, diabetes, Down's syndrome etc.)
  • Any binocular vision anomalies
  • Amblyopia
  • Use of prior myopia control treatment like specialized myopia control spectacles and contact lenses at least in the previous one month.
  • Current use of ocular or systemic medications which, in the investigator's opinion, may significantly affect pupil size, accommodation or refractive state.
  • Participation in any clinical investigation within 30 days of the baseline visit.

Study details
    Myopia

NCT06850168

Essilor International

16 October 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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