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Association Between Plasma D Dimer in Adult CAP and Severity of Inflammatory Response and Survival

Association Between Plasma D Dimer in Adult CAP and Severity of Inflammatory Response and Survival

Recruiting
18 years and older
All
Phase N/A

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Overview

This is an observational study aiming to investigate the association between elevated plasma D-dimer levels and the inflammatory response, as well as the impact on survival in adult patients with community acquired pneumonia.

the study participants will be subjected to sampling for D dimer and calculation of CURB 65 score. this aims to find the relation between them

Description

Community-acquired pneumonia (CAP) is a common and potentially life-threatening infection that affects millions of individuals worldwide each year.

D-dimer is a fibrin degradation product that is elevated in many conditions associated with inflammation and coagulation activation, including pneumonia.

This is an observational study including a minimum of 50 patients with CAP

Patients who will be admitted at Chest department, or coming to the outpatient clinic Ain-Shams University Hospitals with CAP and have the following inclusions:

  1. age ≥18 years
  2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.
  3. Did not have any clinical or radiological signs suggesting Covid pneumonia Exclusion criteria Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.

All patients will be subjected to the following: -

  1. Full medical history, demographics
  2. Thorough clinical examination.
  3. laboratory values (including white blood cell count, CRP, and D-dimer), With pre and post sample known precautions (8).
  4. Radiological findings (CXR).
  5. Severity of illness (based on the CURB-65 score).

Eligibility

Inclusion Criteria:

  • Patients who will be admitted at Chest department, or coming to the outpatient clinic Ain-Shams University Hospitals with CAP and have the following inculsions:
    1. age ≥18 years
    2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.

Exclusion Criteria:

  • Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
  • patients who have any clinical or radiological signs suggesting Covid pneumonia.

Study details
    D-dimer

NCT07199530

Ain Shams University

16 October 2025

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