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Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop

Testing of an Interface for Synchronizing tACS-DBS With a Phase-locked-loop

Recruiting
35-85 years
All
Phase N/A
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  • Simplified (AI rewritten)

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Overview

The investigators aim to test an interface to phase-lock transcranial alternating current stimulation (tACS) and deep brain stimulation (DBS) for future studies investigating the effects of different time-lags between DBS and tACS on the behavioural and neural level. To test if the interface works in patients with DBS, the investigators record EEG during synchronized tACS-DBS in several patients. The investigators hypothesize that they can apply tACS at the desired phase-lags relative to DBS pulses and confirm this with EEG measurements of the DBS and tACS artifact.

Eligibility

Inclusion Criteria:

  • Provision of written informed consent by the patient
  • Age 35 - 85
  • patient groups: Parkinson's disease, essential tremor, dystonia
  • >3 months after surgery for DBS

Exclusion Criteria:

  • Epilepsy or history of seizures
  • Existence of heart pacemaker or other metal implants in the body (except DBS)
  • Pregnancy

Study details
    Deep Brain Stimulation
    Parkinson's Disease (PD)

NCT07139093

Universitätsklinikum Hamburg-Eppendorf

15 October 2025

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