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Efficacy of Manual Toothbrushes in Removing Tooth Stains

Efficacy of Manual Toothbrushes in Removing Tooth Stains

Recruiting
18-70 years
All
Phase 3

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Overview

Efficacy of Manual Toothbrushes in Removing Tooth Stains: A 6-Week Clinical Research Study.

Description

The aim of this study is to evaluate the effectiveness of manual toothbrushes in reducing tooth staining after 6 weeks of unsupervised, daily use by participants.

Eligibility

Inclusion Criteria:

  • Signed Informed Consent Form;
  • Male and female subjects, aged 18-70, inclusive;
  • Good general health and good oral health based on the opinion of the study investigator;
  • Presence of permanent natural anterior teeth (no veneers/crowns/restorations that may interfere with this study scoring procedures);
  • A minimum composite mean of 1.5 ≥ determined by the Lobene Tooth Stain Index;
  • Available for the duration of the study;
  • Clinical evidence of a tendency to form extrinsic stains on anterior teeth.

Exclusion Criteria:

  • Presence of orthodontic appliances/retainers involving scorable teeth;
  • Presence of partial removable/fixed dentures and/or restorations involving scorable teeth;
  • Tumor(s) of the soft or hard tissues of the oral cavity;
  • Obvious signs of periodontal disease rampant caries, or any condition that the dental examiner considers exclusionary from the study;
  • Five or more carious lesions requiring immediate care;
  • Use of antibiotics, stain-inducing medications, and/or on any prescription that might interfere with the study outcome;
  • Concurrent participation in another clinical study;
  • Self-reported pregnancy and/or lactating women;
  • Have used professional whitening product within one (1) year or had a dental prophylaxis (professional dental cleaning) within thirty (30) days - prior to the start of the study;
  • History of allergies to oral care/personal care consumer products or their ingredients;
  • History of alcohol and/or drug abuse.

Study details
    Tooth Discoloration

NCT06486974

Colgate Palmolive

21 October 2025

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FAQs

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A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

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Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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