Overview
Prospective experimental study using PBMC from a limited number of adult patients (15) treated at Nantes University Hospital for a kidney transplant from a related living donor.
The study will be carried out on PBMC from both donors and recipients, collected during visits scheduled as part of the clinical management of the donor/recipient pair.
The study will test the hypothesis that DP8α Tregs expressing CD73, whose frequency in blood increases stably after non-rejected kidney transplants, but not when patients have undergone or will subsequently undergo rejection, are enriched in donor-specific cells, which would be a strong argument in favor of a direct role for these Tregs in preventing transplant rejection, through their ability to inhibit immune responses directed against donor alloantigens.
Eligibility
Inclusion Criteria:
- Adult donor-recipient pair.
- First or second kidney transplant from a related ABO-compatible living donor.
- BMI < 35 for recipients.
- Adult patients.
- Patients weighing over 50 kgs.
Exclusion Criteria:
- Donor/recipient ABO incompatibility
- BMI > 35 for recipients