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Symptoms Burden in Lung Cancer Patients Undergoing Definitive Chemoradiotherapy: Insights From Electronic Patient-Reported Outcomes

Symptoms Burden in Lung Cancer Patients Undergoing Definitive Chemoradiotherapy: Insights From Electronic Patient-Reported Outcomes

Recruiting
18 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

This prospective observational study aims to evaluate symptom burden and symptom clusters among lung cancer patients undergoing definitive concurrent chemoradiotherapy (CRT), based on electronic patient-reported outcomes (ePROs). Patients will complete the validated MDASI-LC and EQ-5D instruments weekly from baseline through the end of CRT and for 12 weeks post-treatment. The study will characterize the longitudinal trajectories of symptom severity and interference, identify distinct symptom clusters and their temporal patterns, and explore patient-level predictors of symptom burden. The findings may support the development of personalized symptom management strategies and improve quality of life during and after CRT.

Eligibility

Inclusion Criteria:

  • Pathologically confirmed unresectable stage III NSCLC or limited-stage SCLC
  • Age ≥ 18 years
  • Receiving definitive chemoradiotherapy
  • Able and willing to complete electronic questionnaires
  • Provided written informed consent

Exclusion Criteria:

  • Severe comorbidities (heart, liver, kidney)
  • Psychiatric illness or cognitive impairment
  • Prior chest or mediastinal radiotherapy

Study details
    Lung Cancer
    Chemoradiotherapy
    Patient-Reported Outcomes (PRO)

NCT07131670

Qian Chu

15 October 2025

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