Overview

this study is to compare no-sedation versus daily interruption of sedation (DIS) in Chronic obstructive pulmonary disease (COPD) patients receiving mechanical ventilation upon the ventilator-free days.

Eligibility

Inclusion Criteria:

• Patients of both sex aged 18 years or older
• The study will include 60 patients divided into 2 equal groups
• Invasive mechanical ventilation
• Patients with COPD patients (post-bronchodilator FEV1/FVC< 70, and under follow through the department outpatient clinic) exacerbation admitted to the ICU and required invasive mechanical ventilation were recruited.

Exclusion Criteria:

Allergy to sedative which will be used

• renal or hepatic impairment
• proven or suspected psychiatric or neurological impairment
• pregnancy