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Acupuncture as Adjuvant Therapy for Glaucoma - Protocol for a Randomized Controlled Trial

Acupuncture as Adjuvant Therapy for Glaucoma - Protocol for a Randomized Controlled Trial

Recruiting
20 years and older
All
Phase N/A

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Overview

This clinical trial used acupuncture as an adjunctive treatment for glaucoma patients. A randomized, controlled trial involving 50 subjects will be conducted and observed for 12 weeks to evaluate the clinical efficacy of acupuncture. This study aims to provide a reference for future clinical treatment guidelines.

Description

This clinical trial utilized acupuncture as an adjunctive treatment for glaucoma patients. It is estimated a randomized clinical trial that 50 subjects will be enrolled and observed for 12 weeks to evaluate the clinical efficacy of acupuncture, providing a reference for future clinical treatment guidelines. Participants will be randomly divided into two groups: Ophthalmic Acupoint Treatment Group and Non-ophthalmological Acupoint Control Group. Participants in the treatment group will undergo acupuncture targeting ophthalmology-related acupuncture points, aiming to elicit the 'De Qi' sensation. Conversely, the control group will receive minimum acupuncture stimulation targeting non-ophthalmic acupuncture points without the intention of achieving the 'De Qi' sensation. Both groups will undergo acupuncture therapy once a week for a total of six sessions and will be observed for twelve weeks. On each visit, intraocular pressure, blood pressure, and heart rate will be assessed. Questionnaires of Glaucoma Symptom Scale (GSS) and The Glaucoma Quality of Life-15 (GQL-15) will be performed. The data of central corneal thickness, optical coherence tomography angiography, optical coherence tomography, visual field, and best-corrected visual acuity will be collected and analyzed before acupuncture and in the 12th week.

Eligibility

Inclusion Criteria:

  1. Primary open angle glaucoma diagnosed at least 3 months ago.
  2. Diagnosed with mild or moderate open angel glaucoma.
  3. Use 1 or 2 kinds of glaucoma drugs.
  4. Age ≥ 20 years old.
  5. Participants sign the informed consent and cooperate with the experimental procedures.

Exclusion Criteria:

  1. Accept any ophthalmic laser or surgery within one year.
  2. High myopia.
  3. Use of any drugs that affect intraocular pressure.
  4. Visual acuity with correction lower than 0.2.
  5. Previous or existing uveitis or retinopathy.
  6. Unable to receive acupuncture treatment continuously or allergic to acupuncture needles.
  7. Pregnancy or breastfeeding.
  8. Refusal to sign the informed consent form.

Study details
    Glaucoma
    Acupuncture
    Intraocular Pressure

NCT05753137

China Medical University Hospital

21 October 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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