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Physical Activity in CKD

Physical Activity in CKD

Recruiting
13-18 years
All
Phase N/A

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Overview

The goal of this is to test the efficacy of a 12-week physical activity intervention in 64 adolescents with CKD.

Description

For youth with chronic kidney disease (CKD), cardiovascular disease (CVD) is a leading cause of morbidity and early mortality. Physical activity is a well-recognized determinant of health and quality of life, but, youth with CKD are less physically active than their healthy peers. Identification of effective strategies to increase physical activity in youth with CKD is paramount to improving outcomes. The investigators will test the efficacy of a 12-week physical activity intervention in 64 adolescents with CKD. Guided by the Multiphase Optimization Strategy (MOST) framework, an optimization trial will identify intervention components that increase average daily moderate to vigorous physical activity by 15 min/day, a clinically meaningful increase. The components will be grounded in established behavioral change theories and be delivered via Way to Health, a web-based platform, to overcome barriers at the point of clinical care where time and resources are limited.

Eligibility

Inclusion criteria:

For adolescent participants:

  1. Males or females age 13 - 18 years
  2. Diagnosis of CKD stage II - V not yet on dialysis or with a transplant
  3. English proficiency
  4. Parental/guardian permission (informed consent), and if applicable, child assent

For caregiver participants:

  1. Parent/legal guardian of an enrolled adolescent participant
  2. English proficiency

Exclusion Criteria:

For adolescent participants:

  1. Pregnant or lactating
  2. Non-ambulatory
  3. Have high physical activity at baseline (>45 min/day of MVPA)
  4. Provide <2 days of physical activity data during the run-in period
  5. Have a condition, such as heart or lung disease, that preclude safely engaging in physical activity
  6. Have received a solid organ transplant
  7. Have limited English proficiency
  8. Are on dialysis
  9. In the opinion of the investigator, are unable to comply with the requirements of the study protocol or are unsuitable for the study for any reason

For caregivers participants:

  1. Limited English proficiency

Study details
    Chronic Kidney Diseases

NCT06624358

Children's Hospital of Philadelphia

15 October 2025

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