Overview
The goal of this observational study is to validate changes in speech as a measure of cognition in individuals at increased risk of Alzheimer's disease and related dementias (ADRD). This study aims to clarify how speech may be affected by Alzheimer's disease.
Participants will complete speech collection sessions and a survey at home using an iPad. Participants can expect to be in the study for 3 years.
Description
Digital technology, including recorded speech, has the capability of providing a wealth of information about early changes to cognition and communication associated with developing Alzheimer's disease pathology, with the potential for highly accessible, yet low-burden measurement. In this project, researchers will recruit a subset of participants from two longitudinal, observational cohort studies enriched for individuals at risk for or living with Alzheimer's disease to record their speech at home with a mobile device, longitudinally. Our interdisciplinary team will then validate digital markers across all stages of Alzheimer's Disease and Related Dementias (ADRD), including the prodromal phase, and can enhance sensitivity and specificity of speech metrics while contributing valuable information about remote, noninvasive, and accessible assessment and disease monitoring.
Eligibility
Inclusion Criteria:
- Must be enrolled in the Wisconsin Alzheimer's Disease Research Center (W-ADRC) Clinical Core or IMPACT studies, or in the Wisconsin Registry for Alzheimer's Prevention (WRAP)
- Cognitively unimpaired or have a diagnosis of Mild Cognitive Impairment (MCI)
- Ages 40-80 years
- Completion of a W-ADRC or WRAP study visit within the past or upcoming 12 months
- Have provided W-ADRC or WRAP with blood plasma Alzheimer's Disease
Exclusion Criteria:
- Not actively enrolled in W-ADRC or WRAP
- Diagnosis of dementia
- Impaired capacity or unwilling to consent
- Major neurological conditions
- Speech disorders