Overview
Assess the effectiveness of manual acupuncture in modulating serum uric acid levels among patients diagnosed with asymptomatic hyperuricemia.
Description
This is a multicenter randomized, single-blind, sham-controlled trial. A total of 260 eligible patients with asymptomatic hyperuricemia will be randomly assigned in a 1:1 ratio to manual acupuncture group or sham acupuncture group.
Eligibility
Inclusion Criteria:
- With serum uric acid (SUA) level >7 mg/dL after 1 month of a low-purine diet.
- No history of gouty arthritis.
- Has not received uric acid-lowering drug treatment or stopped uric acid- lowering drug treatment ≥ 12 weeks.
- 18.5kg/m2 ≤ body mass index (BMI) ≤ 30.0 kg/m2.
- Can write informed consent.
Exclusion Criteria:
- Patients with poorly controlled hypertension: systolic blood pressure (SBP) ≥ 160mmHg, diastolic blood pressure (DBP) ≥ 100 mmHg.
- Patients with poorly controlled diabetes (hemoglobin A1c ≥ 8.4%).
- Patients with severe liver and kidney damage: chronic kidney disease (CKD) ≥ stage 2 or a serum creatinine, urea, alanine, or aspartate aminotransferase level more than twice of the upper limit.
- Patients with blood system diseases, such as acute and chronic leukemia, polycythemia, multiple myeloma, hemolytic anemia, lymphoma, or undergoing chemotherapy for multiple solid tumors.
- Patients with stroke, coronary heart disease, or severe neuropsychological diseases.
- Patients who are pregnant.
- Illiterate or unwilling to accept acupuncture treatment.