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Anterior Cruciate Ligaments: Studying Updates in neuroCognition After Knee Manipulation

Anterior Cruciate Ligaments: Studying Updates in neuroCognition After Knee Manipulation

Recruiting
18-35 years
All
Phase N/A

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Overview

This study will investigate whether knee joint manipulation can improve neurocognitive and neuromuscular performance in individuals with a history of anterior cruciate ligament reconstruction (ACLR). Recruitment will consist of 30 participants aged 18-35 who are 4 months to 5 years post-ACLR and demonstrate measurable reaction time delays. Using a within-subject pre-post design, participants will complete a battery of neurocognitive and neuromuscular assessments, including visuomotor reaction time and dual-task hop testing, before and after knee joint manipulation(s).

The main questions the investigators aim to address are:

Aim 1: Evaluate the feasibility, acceptability, and applicability of integrating knee joint manipulation into post-ACLR rehabilitation using the Implementation and Outcomes Framework.

Aim 2: Determine preliminary efficacy of knee joint manipulation on neurocognitive performance in individuals with ACLR.

Eligibility

Inclusion Criteria:

  • Provided informed consent prior to any study procedures that are performed.
  • Are between the ages of 18 and 35.
  • Have undergone ACLR surgery. All autograft and allograft types are accepted.
  • Are 4-months to 10-years post-ACLR.
  • Injured knee playing or training for sports (recreational or organized) or during physical activity.
  • Have been cleared by a physician to return to activities and/or participate in this study.
  • Are at least the minimally clinical important difference (MCID) above the normative reaction time average for our methods as established by previous literature in at least 1 reaction time task.

Exclusion Criteria:

  • History of concussion in the past 3 months.
  • The participant is pregnant.
  • Have a neurological disorder, including epilepsy.
  • Currently injured or have injured their lower extremity in the past 3 months.
  • Had surgery on multiple ligaments when their ACL was injured.

Study details
    Anterior Cruciate Ligament (ACL) Tear
    Anterior Cruciate Ligament Reconstruction Rehabilitation

NCT07058467

University of North Carolina, Chapel Hill

15 October 2025

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