Overview
The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with placenta previa and placenta accreta spectrum.
Description
The main goal of this case-control study is to quantify the levels of circulating syncytiotrophoblast-derived extracellular vesicles (STBEVs) in maternal blood in a population of women with ultrasound diagnosis of PP with and without postpartum histopathologic diagnosis of PAS, compared to pregnant women with normal placentation.
The secondary aim of this case-control study is to characterize the multi-omics profiling of STBEVs cargo's (proteins, gene and transcripts) isolated from patients diagnosed with PP and PAS compared to the control population.
Eligibility
Inclusion Criteria:
- Pregnant women with diagnosis of placenta previa and accreta spectrum (cases)
- Healthy pregnant women
- > 18 years
Exclusion Criteria:
- < 18 years
- Twin pregnancies
- Chronic Infections
- Cancers
- Unable to give the written consent