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Treatment for PTSD and Tinnitus

Treatment for PTSD and Tinnitus

Recruiting
18 years and older
All
Phase N/A

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Overview

In this study, researchers are examining the best sequence of interventions for posttraumatic stress disorder (PTSD) and tinnitus. Participants will either receive psychotherapy for PTSD first (Cognitive Processing Therapy; CPT), followed by treatment for tinnitus (Cognitive Behavioral Therapy for Tinnitus; CBT-t); or vice-versa. We also aim to identify changes in brain functioning after receiving therapy.

Description

After consenting to this study, study participants will be asked to speak with a study staff member about stressful or traumatic experiences, complete hearing assessments and questionnaires about exposure to traumatic events, PTSD symptoms, mental and physical health problems, such as depression and substance use, head injuries, and tinnitus. Participants who are able and willing may be asked to provide functional magnetic resonance imaging (MRI) scans before and after treatment. Participants will receive treatment for tinnitus and posttraumatic stress disorder (PTSD) in one of two ways: Cognitive Processing Therapy (CPT) first and then Cognitive Behavioral Therapy for Tinnitus (CBT-t) OR CBT-t first, followed by CPT.

Eligibility

Inclusion Criteria:

  • Adult male and female active duty military personnel and veterans seeking treatment for PTSD
  • Diagnosis of PTSD
  • Person has experienced at least one mild traumatic brain injury (concussion)
  • Ability to speak and read English
  • Stable on any psychotropic medications
  • Meets criteria for chronic subjective and bothersome tinnitus
  • Chronic tinnitus is at least possibly related to head injury

Exclusion Criteria:

  • Currently receiving other talk therapies
  • Severe hearing loss that would prevent the participant from benefiting from therapy
  • Current severe suicidal ideation
  • Psychiatric hospitalization in the last 12 months
  • Moderate to severe substance use that would prevent the participant form benefiting from therapy
  • Current manic episode or psychotic symptoms requiring immediate stabilization or hospitalization
  • Significant cognitive impairment
  • Moderate to severe brain damage
  • Neurobiological disorders
  • Temporomandibular joint disorders and/or Meniere's disease that cause acute pain

Study details
    PTSD - Post Traumatic Stress Disorder
    Posttraumatic Stress Disorder (PTSD)
    Tinnitus

NCT07106593

The University of Texas Health Science Center at San Antonio

15 October 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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