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Effect of the New Definition of Epilepsies of the ILAE of 2014 on the Diagnosis After the First Seizure

Effect of the New Definition of Epilepsies of the ILAE of 2014 on the Diagnosis After the First Seizure

Recruiting
18 years and older
All
Phase N/A

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Overview

The present study is a prospective study on the development of seizure frequency, medication adherence, quality of life and cognitive performance after a first epileptic seizure using the new diagnostic criteria for epilepsy of the International League Against Epilepsy of 2014 at the time of diagnosis.

Description

The new diagnostic criteria for epilepsy, which have been in place since 2014, suggest that due to the improved possibilities for early diagnosis and treatment - particularly as a result of improved imaging diagnostics - changes in the incidence rates and severity of the course of epilepsies with different etiologies can be expected.

The group of epilepsies with unclear etiology should now be smaller than in previous studies. The MRI- and EEG-positive patients can now be identified as having structural epilepsy based on the type of lesion, which was not possible in previous studies without differentiated imaging. The fact that these patients can now be treated before a patients can now be treated before a second seizure, the risk of recurrence and the health economic costs should also be reduced and have a positive effect on maintaining cognitive performance and quality of life after a first epileptic seizure.

The aim of the study is to record the consequences of the new epilepsy diagnostic criteria in terms of outcome and treatment. In addition, the investigators will use a questionnaire battery and neuropsychological testing to record the potential neuropsychological deficits, financial and socio-medical consequences of a first seizure or early-stage epilepsy.

Eligibility

Inclusion Criteria:

  • Completion of the 18th year of life
  • first epileptic seizure
  • Ability to understand the patient information and to give written consent
  • Written consent for voluntary participation in the study

Exclusion Criteria:

  • Chronic drug or alcohol abuse in the last two years

Study details
    Seizure
    Epileptic
    Neuropsychology
    Outcome

NCT06836687

University Hospital Marburg

15 October 2025

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