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A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder

A Future Thinking Intervention for Comorbid Tobacco Use Disorder and Bipolar Disorder

Recruiting
18 years and older
All
Phase N/A

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Overview

Future Self-BD is a 6-session virtual intervention that encourages participants to vividly generate personal and positive future events that they anticipate may be benefited by smoking cessation. Each session will be conducted on HIPAA-compliant Zoom and led by the PI (Dr. Gold).

Description

This is a treatment development study that begins with an open non-randomized pilot trial (N = 10) in which we will test the manual developed for Future Self-BD by assessing the acceptability and feasibility of Future Self-BD. After completion of the non-randomized pilot trial and subsequent revisions to the Future Self-BD manual, we will conduct a parallel randomized controlled trial comparing Future Self-BD (N = 30) to a control treatment, Daily Check-Ins (N = 30). Future Self-BD and Daily Check-Ins involve six, weekly, 1.5-2 hour sessions and one 1.5 hour follow-up session one month after completion of the sixth session; thus, participants will be enrolled in the study for a period of 10 weeks. Assessments will occur at all study sessions.

Eligibility

Inclusion Criteria:

  • Adults aged 18 or older
  • Have a diagnosis of BD I or II
  • Have a diagnosis of tobacco use disorder
  • Be engaged in outpatient treatment with a medical provider
  • Be on a stable dose of a mood-stabilizing medication
  • Smoke an average of at least 5 cigarettes per day for the past 30 days at baseline (based on the Heaviness of Smoking Index(Heatherton et al., 1989))
  • Be interested in quitting smoking
  • Not currently or in the past 3 months be receiving smoking cessation treatment.

Exclusion Criteria:

  • Current psychosis
  • Intent to harm oneself with an associated plan and intent to act on suicidal thoughts
  • Experiencing severe symptoms of depression and/or hypomania that may warrant a higher level of care (a Patient Health Questionnaire-9 total score ≥ 20(Kroenke et al., 2001) and/or an Altman Self-Rating Mania Scale total score ≥ 6(Altman et al., 1997) will trigger further clinician evaluation)

Study details
    Bipolar Disorder
    Tobacco Use Disorder

NCT06609902

Massachusetts General Hospital

15 October 2025

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