Overview
This will be a prospective randomized, double-blind study, aiming at investigating the effects of magnesium sulfate on postoperative hypercoagulability in patients undergoing laparoscopic gynecological surgeries under general anesthesia
Description
This randomized, double-blind, controlled study investigates the effects of magnesium sulfate on postoperative hypercoagulability in patients undergoing laparoscopic gynecological surgeries under general anesthesia. Using thromboelastometry, the study aims to assess the impact of magnesium sulfate on blood coagulation parameters. Patients are divided into two groups, with one group receiving magnesium sulfate and the other receiving normal saline. Both patients and investigators are blinded to the treatment allocation. The study will analyze clotting time, clot formation, and coagulation markers to evaluate the therapeutic potential of magnesium sulfate in reducing postoperative hypercoagulability.
Eligibility
Inclusion Criteria:
- ASA I and II patients
- Laparoscopic gynecological surgeries
- age >18 years
- Patients receiving prophylactic anticoagulant therapy 12 hours before surgery based on the Caprini score
- Patients receiving prophylactic anticoagulant therapy 12 hours postoperatively based on the Caprini score.
Exclusion Criteria:
- ASA ≥ III
- age <18 years
- BMI >40 kg/m²
- Pregnancy
- Known hematologic disorders
- Liver/kidney/cardiovascular disease
- Severe anemia (6,5- 7,9 g/dl)
- Inability or refusal to provide informed consent