Overview
The aim of this study is to evaluate the safety and efficacy of homohartonine combined with venetoclax and azacitidine (HVA) versus intensive chemotherapy (IA/DA) or venetoclax combined with azacitidine (VA) in newly diagnosed high-risk AML patients.
Description
The HVA regimen exerts a synergistic pro-apoptotic effect and has demonstrated significant clinical efficacy against R/R AML and also overcomes adaptive resistance observed in the VA regimen. Exploratory work with small sample sizes in first-line settings suggests that combination of HHT and Ven+AZA exhibits potent anti-AML effects with good safety profiles, particularly in overcoming the impact of high-risk factors associated with AML relative to standard treatments. This indicates its potential as a more ideal option for the treatment of newly diagnosed AML with high risk factors. Therefore a prospective, multi-center, randomized controlled clinical study is planned to evaluate the efficacy and safety of the HVA regimen compared to intensive chemotherapy (IA/DA) or Venetoclax plus azacitidine (VA) regimens in newly diagnosed high-risk fit-AML or unfit AML patients.
Eligibility
Inclusion Criteria:
- According to the world health organization (WHO) classification of newly diagnosed with AML patients;
- Age ≥18 years old;
- High-risk patients should meet any of the following criteria: ① High risk group according to the European Leukemia Risk stratification (ELN) 2022; (2) Secondary AML (sAML) which develops from myelodysplastic syndrome (MDS), bone marrow hyperplastic tumor (MPN) or chronic myeloid cell leukemia, et.; (3) Treatment-related AML (t-AML), Patients have a history of cytotoxic treatment record or ionizing radiation therapy.
- Patients did not receive anti-AML therapy (except leukopenia therapy, such as hydroxyurea or cytarabine < 1.0g/d) after the diagnosis of AML;
- Expected survival ≥12 weeks;
- The eastern tumor cooperation group (ECOG) score 3 points or less;
- Kidney function: creatinine clearance acuity 30 ml/min;
- Liver function: ALT < 5 times normal value, bilirubin < 3 times normal value;
- Sign the informed consent form and understand and abide by the plan calls for process.
Exclusion Criteria:
- Acute promyelocytic leukemia;
- With central nervous system leukemia (CNSL) ;
- The cardiac function > level 2;
- The AIDS virus (HIV) infection;
- Other clinical significance of uncontrolled condition, including but not limited to: (1) out of control, or active systemic infection (viruses, bacteria or fungi); (2) chronic hepatitis B virus (HBV) or hepatitis C virus (HCV) requiring treatment; (3) need to actively deal with the merger of the second tumor;
- Can't take oral treatment or having a gastrointestinal disease impact ing the absorption;
- Being allergy to the experimental drugs;
- Pregnant and lactating women;
- Patients who could not understand or adhere to the study protocol;
- Patients deemed by the investigator to be ineligible for enrollment.