Overview
The goal of this research study is to learn about the effects of the RISE-YA intervention on cancer-related fatigue in young adults who are brain cancer survivors.
Description
Primary Objective:
Test the efficacy of RISE-YA to improve CRF
Secondary Objectives:
- Test the efficacy of RISE-YA to improve PA and physical function in fatigued YA brain tumor survivors.
- Determine A) cross-sectional associations of CRF with oxidative phosphorylation (OxPhos) and with inflammation, and B) the effect of RISE-YA on OxPhos and on inflammation.
Exploratory Objective:
Assess the effect of our supervised exercise intervention on patient-reported health-related quality of life, muscle mass development (BMI, skinfold and circumferences [waist, arm, and calf area]), patient-reported dietary intake, and exercise adherence and progression.
Eligibility
Inclusion Criteria:
- Is currently between the ages of 18-39 years
- Their primary brain tumor was diagnosed at age 15-39 years
- Is 6 months to <5 years post curative treatment
- Has been treated with chemotherapy and radiation, given most patients receive both therapies.
- Functional Assessment of Chronic Illness therapy (FACIT)-Fatigue ≤ 43. FACIT-Fatigue will be used as a screener because this 13-item scale can be completed relatively quickly in clinic
- Currently engage in <150 minutes of PA and < 2 sessions of muscle strengthening exercise per week (assessed by Godin Leisure-Time PA Questionnaire)
- Must be able to speak, write, and read English
- No exercise contraindication as assessed by screening with the Physical Activity Readiness Questionnaire PAR-Q+. In addition, participants' care teams will be notified of their participation in the study.
- Must be able to provide informed consent/assent.
Exclusion Criteria:
- Non-English speaking
- Screen failure for exercise safety
- Underlying unstable cardiac or pulmonary disease or symptomatic cardiac disease
- Recent fracture or acute musculoskeletal injury that precludes ability to participate in supervised exercise training sessions
- History of underlying chronic disease, secondary malignances, germline genetic syndrome, or recurrent disease requiring re-irradiation of the brain
- Cognitive and/or major sensory deficits that would impede the completion of research activities and assessments as deemed by the clinical team.
- Self-report of pregnancy
- Prisoners
- Documented developmental disorders (e.g., Autism) or major psychotic illness (e.g., schizophrenia)