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Thailand HIV and Stigma Reduction Study

Thailand HIV and Stigma Reduction Study

Recruiting
18-29 years
Male
Phase N/A

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Overview

This project will develop a multi-component, technology-delivered intervention designed to reduce HIV and intersectional stigma and improve the use of HIV pre-exposure prophylaxis (PrEP) among HIV-negative Thai vulnerable emerging adults (18-29 years).

Eligibility

Aim 1 (Formative Research and Beta-Testing) Transgender women

Inclusion Criteria:

  • Ages between 18 and 29 years
  • Male sex at birth
  • Self-identifies as women, transgender women or culturally identifies with the female spectrum
  • Laboratory-confirmed HIV-negative status
  • Self-reported recent history of condomless sex
  • Able to understand, read and speak Thai
  • Either not started PrEP or currently on PrEP but not adherent (taking ≤3 pills/week) in the past month.

Exclusion Criteria:

  • Have a serious cognitive or psychiatric problem compromising ability to provide informed consent
  • Have active suicidal ideation or major mental illness at the time of interview (these patients will be referred for treatment)
  • Laboratory or clinical findings that would preclude PrEP initiation (e.g., decreased creatinine clearance)
  • Currently enrolled in another HIV intervention study.

Healthcare providers Inclusion criteria

  • Age 18 or above
  • Has provided HIV prevention or treatment services for TGW for at least one year Exclusion criteria
  • None

Aim 2 (Pilot RCT) Transgender women Inclusion criteria

  • Ages between 18 and 29 years
  • Male sex at birth
  • Self-identifies as women, transgender women or culturally identifies with the female spectrum
  • Laboratory-confirmed HIV-negative status
  • Self-reported recent history of condomless sex
  • Able to understand, read and speak Thai
  • Either not started PrEP or currently on PrEP but not adherent (taking ≤3 pills/week) in the past month.

Exclusion criteria

  • Have a serious cognitive or psychiatric problem compromising ability to provide informed consent
  • Have active suicidal ideation or major mental illness at the time of interview (these patients will be referred for treatment)
  • Laboratory or clinical findings that would preclude PrEP initiation (e.g., decreased creatinine clearance)
  • Currently enrolled in another HIV intervention study.

Study details
    Pre-Exposure Prophylaxis

NCT06576648

University of Massachusetts, Worcester

15 October 2025

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