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Vancomycin Reduction Practices (VRP) in the NICU

Vancomycin Reduction Practices (VRP) in the NICU

Recruiting
18 years and older
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

This multi-center, cluster randomized study aimed at improving implementation of vancomycin reducing practices (VRP) in neonatal intensive care units (NICUs). Sites will be recruited and randomized to receive either external facilitation or no external facilitation to assess the effect on center-level fidelity to the core components of VRP implementation. Interventions available to both study arms are directed at hospital staff and includes identification of local champions, educational outreach, unit-level audit & feedback, and use of a clinical decision support tool.

Eligibility

Inclusion Criteria:

  • Level III NICU
  • Affiliated with Kaiser Permanente Northern California (KPNC) or Children's Hospital of Philadelphia Newborn Care Network (CNBCN)
  • Recruited by study team

Exclusion Criteria:

  • Site not recruited for the study

Study details
    Antibiotic Stewardship
    Neonatal Sepsis
    Late-Onset
    Vancomycin

NCT06772675

Children's Hospital of Philadelphia

15 October 2025

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