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Establishing Clinical Utility Evidence for a Novel Alzheimer's Disease Blood-Based Biomarker Assay

Establishing Clinical Utility Evidence for a Novel Alzheimer's Disease Blood-Based Biomarker Assay

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Phase N/A

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Overview

This is a national-level research study of neurologists and dementia specialists. The purpose of this study is to assess the clinical evaluation and management recommendations made by practicing providers for patient simulations with symptoms of cognitive decline.

Description

QURE Healthcare will recruit a nationwide sample of neurologists and dementia specialists to assess the clinical evaluation and management potential of a novel diagnostic tool. The results of this study are expected to contribute to improved quality of care for patients with symptoms of Alzheimer's disease. Findings from this study will be submitted to a national journal for peer-reviewed publication. This study plans to enroll at least 150 healthcare providers.

This study will evaluate the clinical utility of Alzheimer's disease assay by analyzing improvement in the quality of physician decision-making regarding patients with symptoms of Alzheimer's disease, using a validated patient-simulation-based measurement approach, to achieve the following:

  1. Measure variation in clinical decisions among practicing neurologists, specifically in how they detect, measure, and manage Alzheimer's disease in patients with symptoms and/or risk factors of cognitive decline.
  2. Determine whether education on the Alzheimer's disease assay with accompanying test results leads to changes in clinical decision-making with regard to follow-up testing (e.g., CSF analysis, PET imaging), diagnostic accuracy, and treatment recommendations.
  3. Model whether the use of the Alzheimer's disease assay leads to higher-value and/or lower-cost care decisions (including follow-up testing, diagnostics, and treatment) that can lead to more efficient care.
  4. Determine whether the Alzheimer's disease assay results differentially impact treatment decisions for different patient types (use cases).

Eligibility

Inclusion Criteria:

  • Board-certified in neurology for at least two years (and no more than 35 years
  • Average at least 20 hours per week of clinical and patient care duties over the past six months
  • Routinely evaluate patients at risk for Alzheimer's disease
  • Practicing in the United States
  • Able to read English
  • Access to the internet
  • Not participating in a clinical research study of the AD assay
  • Informed, signed, and voluntarily consented to participate in this study

Exclusion Criteria:

  • Board-certified in neurology for less than two years
  • Board certification in neurology over 35 years ago
  • Unable to read English
  • Unable to access the internet
  • Not practicing in the United States
  • Not averaging at least 20 hours per week of clinical or patient care duties over the past six months
  • Participating in a clinical research study of the AD assay
  • Do not voluntarily consent to participate in this study

Study details
    Alzheimer Disease (AD)
    Cognitive Decline

NCT07099001

Qure Healthcare, LLC

15 October 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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