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Time to Clearance of Chlamydia Trachomatis and Neisseria Gonorrhoeae RNA After Treatment: a Prospective Cohort Study

Time to Clearance of Chlamydia Trachomatis and Neisseria Gonorrhoeae RNA After Treatment: a Prospective Cohort Study

Recruiting
18 years and older
All
Phase N/A

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Overview

The aim of this study is to evaluate the negativation time of chlamydial and gonococcal PCRs after treatment for urogenital, oropharyngeal and anal infections.

Eligibility

Inclusion Criteria:

  • - Patients attending the Trait d'Union department at the Nouvel Hôpital Civil for PrEP consultations, AES or HIV infection.
  • Over 18 years of age
  • Male or female
  • Who have had an uncomplicated CT and/or NG infection treated with currently recommended therapies (Ceftriaxone 500mg DU for NG infections, Doxycycline 200mg per day for 1 week for rectal CT infections and Azithromycin 1g DU or Doxycycline 7 days for other CT infections).
  • Subject affiliated to a social health insurance scheme
  • Subject able to understand the aims and risks of the research and to give dated and signed informed consent

Exclusion Criteria:

  • - Complicated CT and/or NG infections: epididymitis, prostatitis, upper genital infection, extra-genital involvement (keratoconjunctivitis, arthritis, skin involvement, Fiessinger-Leroy-reiter syndrome, Fitz-Hugh-Curtis syndrome).
  • Interfering treatments and associated diseases: Severe immunosuppression (HIV infection with CD4 less than 200/mm3, chemotherapy in the last 6 months, active haemopathy, congenital immune deficiency, immunosuppressive treatment including corticosteroid therapy for more than 4 weeks or organ transplant.
  • Impossibility of giving the subject informed information (subject in an emergency situation, difficulties in understanding the subject, etc.).
  • Subject under court protection
  • Subject under guardianship or curatorship

Study details
    Chlamydia Trachomatis
    Neisseria Gonorrhoeae
    Uncomplicated Infections

NCT06216964

University Hospital, Strasbourg, France

15 October 2025

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