Overview
This study compares the effectiveness of low-field MRI (0.55T) with high-field MRI (3T) in prostate cancer screening and image quality. It consists of three phases: optimizing the low-field MRI protocol with healthy volunteers, evaluating image quality in patients with metallic artifacts (like hip prostheses), and assessing low-field MRI in patients with suspicious prostate lesions found on high-field MRI.
Description
This study aims to compare the effectiveness of low-field MRI (0.55T) with traditional high-field MRI (3T) in prostate cancer screening and image quality improvement. The study is conducted in three phases: first, a pilot study with healthy volunteers to optimize the low-field MRI protocol; second, an evaluation of image quality between the two types of MRI in patients with metallic artifacts, particularly due to hip prostheses; and finally, the assessment of low-field MRI in patients with suspicious prostate lesions on high-field MRI (3T).
The goal is to find an accessible solution for prostate cancer screening while maintaining or improving image quality.
Eligibility
Inclusion Criteria:
Work Package1 (WP): 0.55T MRI Protocol Development
- Healthy male volunteers aged 18 and above.
- Agree to be contacted for incidental findings
- Signed informed consent
WP2: 0.55T Prostate MRI with patients with metallic implant(s)
- Adult men (≥18 y.o) with 3T MRI reported as sub-diagnostic due to metallic implants
- Signed informed Consent
WP3: 0.55T Prostate MRI with patients with suspicious lesion(s)
- Adult men (≥18 y.o)
- PI-RADS 4/5 lesions detected on 3T MRI, schedules for targeted biopsy
- Signed informed consent
Exclusion Criteria:
WP1: 0.55T MRI Protocol Development
- Individuals with a history of prostate cancer
- MR Contraindications as listed in the MR Safety Screening form
WP2: 0.55T Prostate MRI with patients with metallic implant(s)
- Contraindications as per MD instructions
- Any condition making the patient unsuitable for the study
- Refusal to be notified in case of incidental finding on the examination
WP3: 0.55T Prostate MRI with patients with suspicious lesion(s)
- Individuals with a history of prostate cancer.
- Contraindications as per MD instructions
- Any condition making the patient unsuitable for the study
- Refusal to be notified in case of incidental finding on the examination