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First-Line Intervention for PTSD - Intensive Treatment

First-Line Intervention for PTSD - Intensive Treatment

Recruiting
18 years and older
All
Phase N/A

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Overview

The goal of this clinical trial is to learn if an intensive program can treat post-traumatic stress disorder (PTSD) in adults getting treatment for the first time, and whether it has lower societal costs. The main questions it aims to answer are:

  • Does an intensive program reduce PTSD symptoms?
  • How expensive is it on a societal level? Researchers will compare the intensive program to the standard weekly treatment to see if the intensive program works to treat PTSD.

Participants will:

  • Get 5 days of intensive treatment in two weeks (with two preparatory and closing sessions), or weekly sessions
  • Get questionnaires and interviews 5 times in 9 months

Eligibility

Inclusion Criteria:

  • 18 years or older
  • PTSD diagnosis according to DSM-5 (CAPS-5);
  • PTSD diagnosis stemming from 2 or more potentially traumatic events (PTEs)
  • seeking first-time treatment for PTSD (or less than 8 sessions);
  • employed (working or on sick leave for less than two years)

Exclusion Criteria:

  • Current psychotic disorder, severe alcohol or substance use disorder, high suicidal intent (MINI-S for DSM-5) and a concrete suicide plan, or severe aggressive behavior that poses danger for others
  • insufficient command of the Dutch language to be able to complete the assessments. This will be determined through clinical judgment at intake.

Study details
    PTSD - Post Traumatic Stress Disorder

NCT06700590

ARQ National Psychotrauma Centre

15 October 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

How long does a clinical trial take place?

The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

Do I get compensated for taking part in clinical trials?

Compensation varies per trial. Some offer payment or reimbursement for time and travel, while others may not.

How safe are clinical trials?

Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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