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HO-1/CREB3 Modulates Golgi Stress in Patients With Sepsis

HO-1/CREB3 Modulates Golgi Stress in Patients With Sepsis

Recruiting
18 years and older
All
Phase N/A

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Overview

This study was an ambispective observational cohort study that included sepsis patients hospitalized in the Intensive care unit (ICU) of the Nankai Hospital. All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.

Description

All patients met the consensus criteria of sepsis-3. The purpose of this study is to investigate the valuable biomarkers for the severity of sepsis and predictors of 30-day mortality for patients with sepsis.

Eligibility

Inclusion Criteria:

  1. Males or females over the age of 18;
  2. Sepsis was diagnosed within 48h which meets SPESIS 3 criteria;
  3. Capable of understanding the purpose and risk of the study;
  4. Patients or proxy must give written informed consent before any assessment is performed.

Exclusion Criteria:

  1. Pregnancy, lactation or perinatal period;
  2. Breast carcinoma;
  3. HIV seropositive or Syphilis seropositive;
  4. Any clinical-relevant condition that might affect study participation and/or study results;
  5. Participation in any other intervention trial;
  6. Unwillingness or inability to following the study protocol in the investigators opinion.

Study details
    Sepsis

NCT06045780

Tianjin Nankai Hospital

21 October 2025

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