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Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors

Phase 1/2 Study to Evaluate TH9619 in the Treatment of Advanced Solid Tumors

Recruiting
18 years and older
All
Phase 1/2
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Overview

This is a first in human, multi-center, open-label, dosage escalation study to determine the recommended dose range of TH9619 in subjects with advanced cancer.

Eligibility

Inclusion Criteria:

  • Must have given written informed consent
  • Histopathologically confirmed advanced cancer (colorectal cancer, head and neck squamous cell cancer, non-small cell lung cancer and gastric cancer (including gastroesophageal junction cancer))
  • Prior treatment with at least one line of cytotoxic systemic therapy for metastatic/unresectable cancer
  • Adult patients (≥18 years of age)
  • Must be willing to comply with study procedures

Exclusion Criteria:

• History or presence of any clinically significant disorders as judged by the Investigator.

Study details
    Solid Tumor
    Colorectal Cancer (CRC)
    Squamous Cell Carcinoma of Head and Neck
    Non-Small Cell Lung Cancer (NSCLC)
    Gastrooesophageal Junction Cancer
    Gastric Cancer

NCT07151040

One-carbon Therapeutics AB

15 October 2025

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FAQs

Learn more about clinical trials

What is a clinical trial?

A clinical trial is a study designed to test specific interventions or treatments' effectiveness and safety, paving the way for new, innovative healthcare solutions.

Why should I take part in a clinical trial?

Participating in a clinical trial provides early access to potentially effective treatments and directly contributes to the healthcare advancements that benefit us all.

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The duration of clinical trials varies. Some trials last weeks, some years, depending on the phase and intention of the trial.

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Clinical trials follow strict ethical guidelines and protocols to safeguard participants' health. They are closely monitored and safety reviewed regularly.
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