Overview
Ketones are naturally produced by our body and can affect our blood sugar levels. Ketones could be important tool for treating disease or recovering from exercise. The purpose of this research is to determine if a ketone drink can increase sugar uptake in our muscles. This research will provide new knowledge about the regulation of blood sugar.
Description
Impaired skeletal muscle glucose uptake following a meal ("insulin resistance"), is a primary risk factor for developing type 2 diabetes. We and others have consistently shown that ingesting exogenous ketones can reduce blood glucose concentration. Mechanistically, this must arise through reduced glucose release (i.e. from liver), and/or increased uptake (i.e. into skeletal muscle). Our current MRC-funded work is focussing on ketone-liver interactions in patients with type 2 diabetes. Here we aim to investigate how KE influence skeletal muscle glucose metabolism.
Eligibility
Inclusion Criteria:
- Age 18-40
Exclusion Criteria:
- Any diagnosed metabolic health condition
- Pregnant
- Smoker
- Diagnosed Cardiovascular disease
- Use of medications deemed by research team to affect study outcomes
- Recent history of musculoskeletal injury
- Aged >40 or <18
- Allergy to ingredients in the supplement, including ketones, lactose or milk protein