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Olanzapine Versus Placebo for Moderately Emetogenic Chemotherapy

Olanzapine Versus Placebo for Moderately Emetogenic Chemotherapy

Recruiting
18 years and older
All
Phase 3
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Overview

A study comparing efficacy of olanzapine versus placebo to prevent nausea and vomiting from moderate emetic risk chemotherapy

Description

A randomized study comparing olanzapine versus placebo in addition to standard antiemetic regimen for preventing nausea and vomiting from moderately emetogenic chemotherapy

Eligibility

Inclusion Criteria:

  • histologically confirmed cancer patients who will be started on first dose of oxaliplatin, irinotecan or carboplatin
  • age of >18 years old

Exclusion Criteria:

  • pregnancy or breast feeding
  • has emetic episode within 24 hours
  • gut obstruction
  • uncontrolled brain metastasis
  • allergy to or current use of olanzapine
  • concomittant moderate or high emetogenic chemotherapy on day 2-5
  • Total bilirubin > 2 mg/dl or creatinine clearance < 30 ml/min
  • unable to swallow drug

Study details
    Chemotherapy Induced Nausea and Vomiting

NCT06850454

Mahidol University

15 October 2025

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