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Rapid Prehospital ACcess to ECPR in Prague

Rapid Prehospital ACcess to ECPR in Prague

Recruiting
18-70 years
All
Phase N/A
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

A prospective pilot feasibility study of prehospital ECPR in patients with refractory OHCA

Description

The aim of this pilot prospective study is to assess the feasibility and effectiveness of a prehospital extracorporeal cardiopulmonary resuscitation (ECPR) system for refractory out-of-hospital cardiac arrest (OHCA) in Prague, compared to a historical cohort of in-hospital ECPR recipients from the Prague OHCA trial.

Eligibility

Inclusion Criteria:

  • Estimated age 18-70 years
  • Refractory out-of-hospital cardiac arrest (3 unsuccessful defibrillations and/or at least 10 minutes of resuscitation in case of pulseless electrical activity)
  • Witnessed cardiac arrest
  • ECPR team available
  • ECPR team alert within 20 minutes from the emergency call

Exclusion Criteria:

  • Unwitnessed cardiac arrest
  • Asystole
  • ETCO2 less than 10 mmHg upon ECPR team arrival
  • Known limitations of intensive care (Do Not Resuscitate - DNR status)
  • Known severe neurological impairment prior to cardiac arrest (mRS 4-6)
  • Suspected or known pregnancy

Study details
    Out of Hospital Cardiac Arrest
    Extracorporeal Cardiopulmonary Resuscitation

NCT06789978

General University Hospital, Prague

15 October 2025

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