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ONO-4538 Study in Patients With Richter's Transformation

ONO-4538 Study in Patients With Richter's Transformation

Recruiting
18 years and older
All
Phase 2
  • Technical (Original)
  • Simplified (AI rewritten)

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Overview

Investigate the efficacy and safety of ONO-4538 in patients with Richter's transformation

Eligibility

Inclusion Criteria:

  • Histological diagnosis of diffuse large B-cell lymphoma (DLBCL)-type or Hodgkin lymphoma(HL)-type Richter's transformation with a history of chronic lymphocytic leukemia (CLL) or small lymphocytic lymphoma (SLL)
  • In the case of DLBCL-type Richter's transformation, refractory, intolerant or ineligible for treatment of DLBCL
  • Patients with measurable disease
  • Eastern Cooperative Oncology Group (ECOG) performance status of 0 or 1
  • Expected to survive for 90 days or more

Exclusion Criteria:

  • Serious complications
  • Active multiple cancers
  • Active central nervous system (CNS) disease
  • History of allogeneic hematopoietic stem cell transplantation

Study details
    Richter's Transformation

NCT06936943

Ono Pharmaceutical Co. Ltd

15 October 2025

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