Overview

To verify whether albumin administration to achieve serum concentration above 30g/L (treated group) and its maintenance within plasmatic physiologic range (above 30 g/L) for five days diminishes rate of AKI at Day 7 after liver transplantation as compared to restrained albumin administration (when serum concentration is at 20 g/L or below (control)).

Eligibility

Inclusion Criteria:

• Male and female subjects equal or above 18 yrs old.
• Recipients of primary liver allografts from a deceased donor (including after cardiac death) and as a single organ (liver only).
• Capability of understanding the purpose and risks of the study.
• Written informed consent

Exclusion Criteria:

• Fulminant hepatitis
• Kidney injury at baseline (Estimated Glomerular Filtration Rate < 50 ml/min in Modification of diet in renal disease-6) including hepatorenal syndrome
• Use of an induction agent Basiliximab at liver transplantation
• Protected person (adults legally protected, under judicial protection, guardianship, or supervision), person deprived of their liberty
• At the time of randomisation, participation to another interventional study