Overview
To determine whether there is a role for Tamsulosin, A Selective Alpha-1 Adrenergic Blocker, as therapy in children with Posterior Urethral Valve post valve ablation , and whether there are side effects involved.
Description
We aim to evaluate the safety and efficacy of alpha adrenergic blocker, tamsulosin, in children with posterior urethral valves regarding:
- Effect on upper urinary tract (Hydronephrosis improvement, Vesicoureteric Reflux resolution and renal function)
- Effect on bladder outlet resistance
- Effect on intravesical detrusor pressure
- Febrile Urinary Tract Infection recurrence
Eligibility
Inclusion Criteria:
- Children with a diagnosis of PUV.
Exclusion Criteria:
- Patients with other conditions that can potentially affect lower or upper urinary tract functions (e.g. spinal dysraphism, anorectal malformation and prune belly syndrome)
- Patients who were treated with urinary diversion as vesicostomy or cutaneous ureterostomy.
- Patients who had primary treatment of PUV ablation at other hospitals.
- Contraindications to α blocker treatment.
- Patients who refuse to participate in the study